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Concentration Protocol of rhenium-188 Perrhenate Eluted From tungsten-188/rhenium-188 Generator for the Preparation of High-Yield rhenium-188-labelled Radiopharmaceuticals

Anupriya Chhabra, Yogesh Rathore, Priya Bhusari, Rakhee Vatsa, Bhagwant R Mittal, Jaya Shukla

Nucl Med Commun. 2018 Oct;39(10):957-959.

PMID: 30086075

Abstract:

Rhenium-188 (Re) is a β, γ emitter and considered a theranostic radionuclide. It is used for bone pain palliation, treatment of unresectable hepatocellular carcinoma, skin keloids, etc. Re perrhenate is eluted from a W/Re generator in large volumes (8-14 ml) of 0.9% normal saline. Concentrating Re to 1-2 ml volume is important for high radiolabelling yield of various Re radiopharmaceuticals, especially when the generator is old. For this, ion exchange column was prepared in-house, and Re was concentrated using silver ion exchange column and QMA cartridge. Re perrhenate eluted in saline was concentrated to 1 ml with more than 99% yield.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP7440155 Rhenium Rhenium 7440-15-5 Price
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