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Concentrations of Serum Free Light Chains in Kappa and Lambda Lesions in Light-Chain Myelomas

Concentrations of Serum Free Light Chains in Kappa and Lambda Lesions in Light-Chain Myelomas

Gurmukh Singh

Lab Med. 2019 Apr 8;50(2):189-193.

PMID: 30423164

Abstract:

Background:
Concentration of serum free light chains has been promoted as an assay in the evaluation of monoclonal gammopathic manifestations. A high false-positive rate in patients without monoclonal gammopathic manifestations and a high false-negative rate in patients with those manifestations have been reported. The false-negative rate for lambda chain-associated lesions is higher than that for kappa chain-associated lesions.
Objective:
To assess the serum free light chains in light-chain myelomas.
Methods:
Concentrations of involved and uninvolved serum free light chains were retrospectively reviewed in patients with light-chain myelomas.
Results:
The highest recorded levels of involved light chains in kappa-chain myelomas and lambda-chain myelomas were comparable. The levels of uninvolved light chains were higher, although not statistically significantly, in lambda-chain lesions.
Conclusions:
The results of serum free light chains in light-chain myelomas support the clinical usefulness of the assay in monitoring patients with light chain myeloma.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42411684	Lambda Light Chains (Free) from human myeloma sera			Price

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