Home
Resources
Publications
Concerted Expression of eotaxin-1, eotaxin-2, and eotaxin-3 in Human Bronchial Epithelial Cells

Concerted Expression of eotaxin-1, eotaxin-2, and eotaxin-3 in Human Bronchial Epithelial Cells

Akiko Komiya, Hiroyuki Nagase, Hirokazu Yamada, Takashi Sekiya, Masao Yamaguchi, Yasuyuki Sano, Nobuo Hanai, Akiko Furuya, Ken Ohta, Kouji Matsushima, Osamu Yoshie, Kazuhiko Yamamoto, Koichi Hirai

Cell Immunol. 2003 Oct;225(2):91-100.

PMID: 14698143

Abstract:

Eotaxin-1/CCL11, eotaxin-2/CCL24, and eotaxin-3/CCL26 bind specifically and exclusively to CC chemokine receptor (CCR) 3, which is a potential therapeutic target in treating the peribronchial eosinophilia associated with allergic airway diseases. Bronchial epithelial cells represent an important source of chemokines, and thus we investigated in vitro and in vivo expression of eotaxin-2 and eotaxin-3 in bronchial epithelial cells in comparison with that of eotaxin-1. Immunohistochemistry showed increased expression of both eotaxin-2 and eotaxin-3 in addition to eotaxin-1 in asthmatics. Considerable amounts of eotaxins were secreted by bronchial epithelial lineage. As with eotaxin-1 production, generation of eotaxin-2 and eotaxin-3 by bronchial epithelial cells was up-regulated by IL-4 and IL-13, and attenuated by IFN-gamma and glucocorticoids. In addition to eotaxin-1 expression, but also eotaxin-2 and eotaxin-3 expression in the bronchial epithelium should be taken into consideration when developing the therapeutic strategies to treat eosinophilic airway diseases.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248777	Eotaxin-2/CCL24 human			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: