Home
Resources
Publications
Conformational Studies of a Novel Cationic Glycolipid, Glyceroplasmalopsychosine, From Bovine Brain by NMR Spectroscopy

Conformational Studies of a Novel Cationic Glycolipid, Glyceroplasmalopsychosine, From Bovine Brain by NMR Spectroscopy

Naoko Iida-Tanaka, Toshiyuki Hikita, Sen-itiroh Hakomori, Ineo Ishizuka

Carbohydr Res. 2002 Oct 11;337(19):1775-9.

PMID: 12423957

Abstract:

A novel glycosphingolipid containing a long chain aldehyde conjugated to galactose and glycerol, Gro1(3)-O-CH((CH(2))(n)CH(3))-O-6Galbeta-sphingosine (glyceroplasmalopsychosine) has been studied by NMR spectroscopy (Hikita et al. J. Biol. Chem. 2001, 276, 23084-23091). We further report here on the conformation showing the galactose and the glycerol at the end of two parallel hydrophobic chains, i.e. the sphingosine and the fatty aldehyde. This is proposed based on the interproton distances derived from ROESY experiments and 3 J (H,H) coupling constants. The absence of any intraresidual NOEs between protons in the glycerol residue suggested that the C-C-2 and C-C-3 bonds in the glycerol may be rotating freely, supporting the proposed conformation in which the unique terminal glycerol is in an environment with a minimal steric hindrance. The present study proposes a conformation of glyceroplasmalopsychosine greatly different from the two conventional plasmalopsychosines possessing a fatty aldehyde chain oriented in an opposite direction to the sphingosine.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2238906	Psychosine from bovine brain		2238-90-6	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: