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Congo Red and Amyloids: History and Relationship

Congo Red and Amyloids: History and Relationship

Elmira I Yakupova, Liya G Bobyleva, Ivan M Vikhlyantsev, Alexander G Bobylev

Biosci Rep. 2019 Jan 15;39(1):BSR20181415.

PMID: 30567726

Abstract:

Staining with Congo Red (CR) is a qualitative method used for the identification of amyloids in vitro and in tissue sections. However, the drawbacks and artefacts obtained when using this dye can be found both in vitro and in vivo Analysis of scientific data from previous studies shows that CR staining alone is not sufficient for confirmation of the amyloid nature of protein aggregates in vitro or for diagnosis of amyloidosis in tissue sections. In the present paper, we describe the characteristics and limitations of other methods used for amyloid studies. Our historical review on the use of CR staining for amyloid studies may provide insight into the pitfalls and caveats related to this technique for researchers considering using this dye.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AS24378	Congo Red-(biphenyl-d8)			Price

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