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Construction of a Junction DNA Nanostructure and Modulation of the Junction Switching to Quadruplexes

Yanwei Cao, Xiaoxuan Xiang, Renjun Pei, Yang Li, Yuting Yan, Xinhua Guo

R Soc Open Sci. 2017 Dec 20;4(12):171337.

PMID: 29308258

Abstract:

A junction DNA nanostructure has been successfully built in lithium acetate buffer solution at a near-neutral pH value through the connection of two slipped junction structures that are formed by G-rich and C-rich strands. The GC-rich duplex junctions in the nanostructure can be switched to G-quadruplexes and i-motifs in weakly acidic potassium acetate solution, which leads to the assembly of DNA nanostructures composed of alternating quadruplex and duplex DNA structures. The transformation between different DNA nanoarchitectures may be applied to the operation of 'DNA nanomachines'.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP127082-A Potassium acetate solution Potassium acetate solution 127-08-2 Price
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