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Control Synthesis, Subtle Surface Modification of Rare-Earth-Doped Upconversion Nanoparticles and Their Applications in Cancer Diagnosis and Treatment

Control Synthesis, Subtle Surface Modification of Rare-Earth-Doped Upconversion Nanoparticles and Their Applications in Cancer Diagnosis and Treatment

Enlv Hong, Lumin Liu, Liming Bai, Chunhui Xia, Lei Gao, Liwen Zhang, Baiqi Wang

Mater Sci Eng C Mater Biol Appl. 2019 Dec;105:110097.

PMID: 31546381

Abstract:

Rare earth doped upconversion nanoparticles (UCNPs) are a new class of luminescent materials that can absorb long-wavelength near-infrared photons and emit short-wavelength UV-visible photons. UCNPs have little damage to biological tissues, have deep tissue penetration ability, have no background fluorescence noise interference, have high imaging sensitivity, and have no photobleaching effect. In the field of biomedicine, especially in the field of diagnosis and treatment of cancer, a wide range of research interests has arisen. In this paper, we briefly introduce the luminescent principle of rare-earth doped UCNPs, discuss several widely used control synthesis and modification methods, and focus on the research progress of UCNPs in detection of cancer cells, photodynamic therapy (PDT) and photothermal therapy (PTT) field. We also summarize the application of UCNPs as a diagnostic and therapeutic integrated nanoplatform in the diagnosis and treatment of cancer. At last, we explore the application challenge and prospect of UCNPs in oncology field.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS767103	Rare earth doped upconversion nanoparticles			Price

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