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Controlled Microstructuring of Janus Particles Based on a Multifunctional Poly(ethylene Glycol)

Controlled Microstructuring of Janus Particles Based on a Multifunctional Poly(ethylene Glycol)

Ekaterina Sokolovskaya, Jaewon Yoon, Asish C Misra, Stefan Bräse, Jörg Lahann

Macromol Rapid Commun. 2013 Oct;34(19):1554-9.

PMID: 23982931

Abstract:

A novel water insoluble, multifunctional poly(ethylene glycol), poly(hydrazide ethylene glycol-co-benzyl glycidyl ether) (P(HZ-co-BnGE)), is synthesized via thiol-ene click reaction of poly(allyl glycidyl ether-co-benzyl glycidyl ether) (P(AGE-co-BnGE)). The base polymer P(AGE-co-BnGE) is previously prepared by anionic ring-opening copolymerization of the corresponding monomers. To demonstrate utility, bicompartmental microspheres and microcylinders containing P(HZ-co-BnGE) in one of the compartments are prepared via electrohydrodynamic (EHD) co-jetting. Next, spatially controlled surface reactivity toward sugars is demonstrated by selective binding of 2α-mannobiose to the P(HZ-co-BnGE) compartment only, as confirmed by a carbohydrate-lectin-binding assay. These sugar-reactive hydrazide-presenting microparticles have potential applications for glyco-targeted drug delivery.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP15548397	2α-Mannobiose		15548-39-7	Price

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