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Controlled Release of Dexamethasone Sodium Phosphate With Biodegradable Nanoparticles for Preventing Experimental Corneal Neovascularization

Controlled Release of Dexamethasone Sodium Phosphate With Biodegradable Nanoparticles for Preventing Experimental Corneal Neovascularization

Bing Wang, Yating Tang, Yumin Oh, Nicholas W Lamb, Shiyu Xia, Zheng Ding, Baiwei Chen, María J Suarez, Tuo Meng, Vineet Kulkarni, Charles G Eberhart, Laura M Ensign, Walter J Stark, Justin Hanes, Qingguo Xu

Nanomedicine. 2019 Apr;17:119-123.

PMID: 30677499

Abstract:

Corneal neovascularization (CNV) leads to the loss of corneal transparency and vision impairment, and can ultimately cause blindness. Topical corticosteroids are the first line treatment for suppressing CNV, but poor ocular bioavailability and rapid clearance of eye drops makes frequent administration necessary. Patient compliance with frequent eye drop application regimens is poor. We developed biodegradable nanoparticles (NP) loaded with dexamethasone sodium phosphate (DSP) using zinc ion bridging, DSP-Zn-NP, with dense coatings of poly(ethylene glycol) (PEG). DSP-Zn-NP were safe and capable of providing sustained delivery of DSP to the front of the eye following subconjunctival (SCT) administration in rats. We reported that a single SCT administration of DSP-Zn-NP prevented suture-induced CNV in rats for two weeks. In contrast, the eyes receiving SCT administration of either saline or DSP solution developed extensive CNV in less than 1 week. SCT administration of DSP-Zn-NP could be an effective strategy in preventing and treating CNV.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2392394-B	Dexamethasone Sodium Phosphate		2392-39-4	Price

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