Home
Resources
Publications
Copolythiophene-derived Colorimetric and Fluorometric Sensor for Visually Supersensitive Determination of Lipopolysaccharide

Copolythiophene-derived Colorimetric and Fluorometric Sensor for Visually Supersensitive Determination of Lipopolysaccharide

Minhuan Lan, Jiasheng Wu, Weimin Liu, Wenjun Zhang, Jiechao Ge, Hongyan Zhang, Jiayu Sun, Wenwen Zhao, Pengfei Wang

J Am Chem Soc. 2012 Apr 18;134(15):6685-94.

PMID: 22452659

Abstract:

3-Phenylthiophene-based water-soluble copolythiophenes (CPT1) were designed for colorimetric and fluorometric detection of lipopolysaccharide (LPS). The sensor (CPT1-C) shows a high selectivity to LPS in the presence of other negatively charged bioanalytes as well an extreme sensitivity with the detection limit at picomolar level, which is the lowest ever achieved among all synthetic LPS sensors available thus far. Significantly, the sensing interaction can be apparently observed by the naked eyes, which presents a great advantage for its practical applications. The appealing performance of sensor was demonstrated to originate from the multiple electrostatic and hydrophobic cooperative interactions, synergetic with signal amplification via the conformational change of the 3-phenylthiophene-based copolymer main chain. As a straightforward application, CPT1-C is capable of rapidly discriminating the Gram-negative bacteria (with LPS in the membrane) from Gram-positive bacteria (without LPS).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2404877	3-Phenylthiophene		2404-87-7	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: