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Copper-catalyzed Three- Five- Or Seven-Component Coupling Reactions: The Selective Synthesis of Cyanomethylamines, N,N-bis(cyanomethyl)amines and N,N'-bis(cyanomethyl)methylenediamines Based on a Strecker-type Synthesis

Copper-catalyzed Three- Five- Or Seven-Component Coupling Reactions: The Selective Synthesis of Cyanomethylamines, N,N-bis(cyanomethyl)amines and N,N'-bis(cyanomethyl)methylenediamines Based on a Strecker-type Synthesis

Norio Sakai, Nobuaki Takahashi, Daiki Inoda, Reiko Ikeda, Takeo Konakahara

Molecules. 2013 Oct 10;18(10):12488-99.

PMID: 24152671

Abstract:

We have demonstrated that a cooperative catalytic system comprised of CuCl and Cu(OTf)(2) could be used to effectively catalyse the three-, five- and seven-component coupling reactions of aliphatic or aromatic amines, formaldehyde, and trimethylsilyl cyanide (TMSCN), and selectively produce in good yields the corresponding cyanomethylamines, N,N-bis(cyanomethyl)amines and N,N'-bis(cyanomethyl)methylenediamines.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP920683	N,N-Bis(trimethylsilyl)methylamine		920-68-3	Price

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