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Copper(II)-bis(thiosemicarbazonato) Complexes as Anti-Chlamydial Agents

Copper(II)-bis(thiosemicarbazonato) Complexes as Anti-Chlamydial Agents

James W Marsh, Karrera Y Djoko, Alastair G McEwan, Wilhelmina M Huston

Pathog Dis. 2017 Sep 29;75(7).

PMID: 28830076

Abstract:

Lipophilic copper (Cu)-containing complexes have shown promising antibacterial activity against a range of bacterial pathogens. To examine the susceptibility of the intracellular human pathogen Chlamydia trachomatis to copper complexes containing bis(thiosemicarbazone) ligands [Cu(btsc)], we tested the in vitro effect of CuII-diacetyl- and CuII-glyoxal-bis[N(4)-methylthiosemicarbazonato] (Cu(atsm) and Cu(gtsm), respectively) on C. trachomatis. Cu(atsm) and to a greater extent, Cu(gtsm), prevented the formation of infectious chlamydial progeny. Impacts on host cell viability and respiration were also observed in addition to the Chlamydia impacts. This work suggests that copper-based complexes may represent a new lead approach for future development of new therapeutics against chlamydial infections, although host cell impacts need to be fully explored.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP90276587	Lead ionophore II		90276-58-7	Price

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