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Copper-promoted N-cyclopropylation of Anilines and Amines by Cyclopropylboronic Acid

Sébastien Bénard, Luc Neuville, Jieping Zhu

Chem Commun (Camb). 2010 May 21;46(19):3393-5.

PMID: 20361101

Abstract:

Reaction of anilines, primary and secondary aliphatic amines with cyclopropylboronic acid in dichloroethane in the presence of Cu(OAc)(2) (1 equiv.), 2,2'-bipyridine (1 equiv.) and sodium carbonate or sodium bicarbonate (2 equiv.) under air atmosphere afforded the corresponding N-cyclopropyl derivatives in good to excellent yields.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP411235579 Cyclopropylboronic acid Cyclopropylboronic acid 411235-57-9 Price
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