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Core-shell Hollow Microspheres of Magnetic Iron oxide@amorphous Calcium Phosphate: Synthesis Using Adenosine 5'-triphosphate and Application in pH-responsive Drug Delivery

Core-shell Hollow Microspheres of Magnetic Iron oxide@amorphous Calcium Phosphate: Synthesis Using Adenosine 5'-triphosphate and Application in pH-responsive Drug Delivery

Bing-Qiang Lu, Ying-Jie Zhu, Feng Chen, Chao Qi, Xin-Yu Zhao, Jing Zhao

Chem Asian J. 2014 Oct;9(10):2908-14.

PMID: 25100227

Abstract:

Drug nanocarriers with magnetic targeting and pH-responsive drug-release behavior are promising for applications in controlled drug delivery. Magnetic iron oxides show excellent magnetism, but their application in drug delivery is limited by low drug-loading capacity and poor control over drug release. Herein, core-shell hollow microspheres of magnetic iron oxide@amorphous calcium phosphate (MIO@ACP) were prepared and investigated as magnetic, pH-responsive drug nanocarriers. Hollow microspheres of magnetic iron oxide (HMIOs) were prepared by etching solid MIO microspheres in hydrochloric acid/ethanol solution. After loading a drug into the HMIOs, the drug-loaded HMIOs were coated with a protective layer of ACP by using adenosine 5'-triphosphate (ATP) disodium salt (Na2 ATP) as stabilizer, and drug-loaded core-shell hollow microspheres of MIO@ACP (HMIOs/drug/ACP) were obtained. The as-prepared HMIOs/drug/ACP drug-delivery system exhibits superparamagnetism and pH-responsive drug-release behavior. In a medium with pH 7.4, drug release was slow, but it was significantly accelerated at pH 4.5 due to dissolution of the ACP shell. Docetaxel-loaded core-shell hollow microspheres of MIO@ACP exhibited high anticancer activity.

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IAR42411316	Guanosine-d14 5′-triphosphate disodium salt solution	Price
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