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Corneal Anesthesia Following Application of 0.4% Oxybuprocaine Hydrochloride Ophthalmic Solution to Normal Feline Eyes

Corneal Anesthesia Following Application of 0.4% Oxybuprocaine Hydrochloride Ophthalmic Solution to Normal Feline Eyes

Valentina Giudici, Sophia Baeza, Jean-Yves Douet, Alain Regnier

Vet Ophthalmol. 2015 Mar;18(2):141-6.

PMID: 24824864

Abstract:

Objective:
To evaluate the loss and recovery of corneal sensitivity after instillation of 0.4% oxybuprocaine hydrochloride solution in the normal feline eye.
Animal studied:
Eighteen European shorthair cats free of ocular disease
Procedures:
Baseline corneal touch threshold (CTT) readings were obtained bilaterally with a Cochet-Bonnet aesthesiometer prior to treatment. Subsequently, each cat received a single drop of 0.4% oxybuprocaine ophthalmic solution in the right eye and one drop of sterile 0.9% NaCl in the left eye to serve as control. The corneal touch threshold (CTT) of both eyes was then measured 1 min after drug administration and every 5 min for 60 min. The potential for ocular irritation following oxybuprocaine application was also evaluated.
Results:
Baseline CTT readings were not significantly different (P > 0.05) between the control and oxybuprocaine-treated eyes with values of 1.75 ± 0.31 cm and 1.75 ± 0.30 cm, respectively. In control eyes, mean CTT did not significantly change (P > 0.05) during the study period. By contrast, after oxybuprocaine application mean CTT was significantly reduced from baseline (P < 0.05) for 45 min. Maximal corneal anesthesia, with a CTT value of 0, was achieved at 1 and 5 min in all treated eyes. A markedly reduced mean CTT of 0.14 ± 0.23 cm was still present at 20 min. Age and gender did not significantly affect corneal anesthesia. No clinically relevant ocular side effects occurred during the observation period.
Conclusion:
This is the first study that provides objective information on the depth and duration of corneal anesthesia following instillation of oxybuprocaine in healthy feline eyes.

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