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Corpora Amylacea Deposition in the Hippocampus of Patients With Mesial Temporal Lobe Epilepsy: A New Role for an Old Gene?

Corpora Amylacea Deposition in the Hippocampus of Patients With Mesial Temporal Lobe Epilepsy: A New Role for an Old Gene?

Abhijit Das, Shabeesh Balan, Anila Mathew, Venkataraman Radhakrishnan, Moinak Banerjee, Kurupath Radhakrishnan

Indian J Hum Genet. 2011 May;17 Suppl 1(Suppl 1):S41-7.

PMID: 21747587

Abstract:

Background:
Mesial temporal lobe epilepsy (MTLE) is the most common medically refractory epilepsy syndrome in adults, and hippocampal sclerosis (HS) is the most frequently encountered lesion in patients with MTLE. Premature accumulation of corpora amylacea (CoA), which plays an important role in the sequestration of toxic cellular metabolites, is found in the hippocampus of 50-60% of the patients who undergo surgery for medically refractory MTLE-HS. However, the etiopathogenesis and clinical importance of this phenomenon are still uncertain. The ABCB1 gene product P-glycoprotein (P-gp) plays a prominent role as an antiapoptotic factor in addition to its efflux transporter function. ABCB1 polymorphism has been found to be associated with downregulation of P-gp expression. We hypothesized that a similar polymorphism will be found in patients with CoA deposition, as the polymorphism predisposes the hippocampal neuronal and glial cells to seizure-induced excitotoxic damage and CoA formation ensues as a buffer response.
Materials and methods:
We compared five single nucleotide polymorphisms in the ABCB1 gene Ex06+139C/T (rs1202168), Ex 12 C1236T (rs1128503), Ex 17-76T/A (rs1922242), Ex 21 G2677T/A (rs2032582), Ex26 C3435T (rs1045642) among 46 MTLE-HS patients of south Indian ancestry with and without CoA accumulation.
Results:
We found that subjects carrying the Ex-76T/A polymorphism (TA genotype) had a five-times higher risk of developing CoA accumulation than subjects without this genotype (Odds ratio 5.0, 95% confidence intervals 1.34-18.55; P = 0.016).
Conclusion:
We speculate that rs1922242 polymorphism results in the downregulation of P-gp function, which predisposes the hippocampal cells to seizure-induced apoptosis, and CoA gets accumulated as a buffer response.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1233332370	Ex26		1233332-37-0	Price

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