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[Correlation Between in Vitro Release and in Vivo Absorption of Sustained-Releasing Tablets of Neostigmine Bromide]

[Correlation Between in Vitro Release and in Vivo Absorption of Sustained-Releasing Tablets of Neostigmine Bromide]

Wen Luo, Qun-You Tan, Hua-Rong Xiong, Chun-Jing Zhao, Jing-Qing Zhang

Sichuan Da Xue Xue Bao Yi Xue Ban. 2013 Jan;44(1):80-3.

PMID: 23600216

Abstract:

Objective:
To determine the correlation between in vitro release and in vivo absorption of sustained-releasing tablets of neostigmine bromide.
Methods:
Water was used as dissolution medium to measured in vitro release of neostigmine bromide. After a single oral administration of 100 mg neostigmine bromide to rabbits, the plasma concentrations of neostigmine bromide in the rabbits were determined by HPLC. The compartment model and deconvolution method were employed to explain the in vitro-in vivo correlation.
Results:
Using Y as cumulative in vitro release and Fa as percentage of absorption, the regression equation was established: Fa = 0.9298Y + 4.6074, r = 0.9961. The input function of R = 2.0163Y-11.242,r = 0.9270.
Conclusion:
The correlation between in vitro release and in vivo absorption of neostigmine bromide is good.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP114807-A	Neostigmine bromide		114-80-7	Price

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