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Corticosterone 21-acetate in Vivo Induces Acute Stress in Chicken Thymus: Cell Proliferation, Apoptosis and Cytokine Responses

Corticosterone 21-acetate in Vivo Induces Acute Stress in Chicken Thymus: Cell Proliferation, Apoptosis and Cytokine Responses

A Franchini, E Marchesini, E Ottaviani

Histol Histopathol. 2004 Jul;19(3):693-9.

PMID: 15168329

Abstract:

In vivo effects of acute stress induced by corticosterone 21-acetate in male Gallus domesticus thymus are studied and the steroid actions are evaluated in terms of cell proliferation, apoptosis and cytokine response in 10- and 21-day-old chickens. Steroid treatment induced thymocyte apoptosis and cell death decreased in the cortical-medullar direction and was more evident in younger animals. 24 h after treatment, the observed effect was reversed. The mitotic activity and thymic cells containing cytokine-like molecules were also affected. Indeed, the acute stress stimulated cytokine immunoreactivity to anti-IL-1alpha, IL-6 and TNF-alpha antibodies both in epithelial cells and interdigitating cells located in medullar and cortical-medullar regions. The increased cytokine expression observed after 12 h was maintained after 24 h. The comparison between 10- and 21-day-old chickens showed a lower number of cells containing cytokine-like molecules in younger specimens. The present findings suggest that cytokines activated by acute stress in vivo could contribute to restoring immunological homeostasis and influence thymic glucocorticoid-mediated functions.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1173268	Corticosterone 21-acetate		1173-26-8	Price

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