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Cross-coupling of Cyclopropyl- And Cyclobutyltrifluoroborates With Aryl and Heteroaryl Chlorides

Gary A Molander, Paul E Gormisky

J Org Chem. 2008 Oct 3;73(19):7481-5.

PMID: 18759480

Abstract:

Suitable conditions were found for the Suzuki-Miyaura cross-coupling reaction of potassium cyclopropyl- and cyclobutyltrifluoroborates with aryl chlorides. Both of these secondary alkyl trifluoroborates coupled in moderate to excellent yield with electron-rich, electron-poor, and hindered aryl chlorides to give a variety of substituted aryl cyclopropanes and cyclobutanes.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1065010889 Potassium cyclobutyltrifluoroborate Potassium cyclobutyltrifluoroborate 1065010-88-9 Price
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