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Cross-coupling of Mesylated Phenol Derivatives With Potassium Cyclopropyltrifluoroborate

Gary A Molander, Floriane Beaumard, Terren K Niethamer

J Org Chem. 2011 Oct 7;76(19):8126-30.

PMID: 21888362

Abstract:

C-O activation of mesylates by a palladium catalyst and subsequent cross-coupling with potassium cyclopropyltrifluoroborate have been achieved with high yield. Both electron-enriched and electron-deficient aryl mesylates are suitable electrophilic partners for the Suzuki-Miyaura reaction. The scope was successfully extended to heteroaryl mesylates with yields up to 94%.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1065010878 Potassium cyclopropyltrifluoroborate Potassium cyclopropyltrifluoroborate 1065010-87-8 Price
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