Home
Resources
Publications
Crystal Structure and Microstructure of Cholesteryl Oleyl Carbonate

Crystal Structure and Microstructure of Cholesteryl Oleyl Carbonate

Pradip Das, Joyes De

Chem Phys Lipids. 2011 Jan;164(1):33-41.

PMID: 20951687

Abstract:

The crystal structure as well as the microstructure, i.e., size and strain, of crystallites of cholesteryl oleyl carbonate was determined from X-ray powder diffraction data. The X-ray line broadening was analyzed through the refinement of TCH-pseudo-Voigt function parameters (isotropic effects) and the refinement of multipolar functions, i.e., symmetrized cubic harmonics (anisotropic effects). The crystal structure turns out to be primitive monoclinic, space group Pc, type I monolayer having two molecules per unit cell with parameters: a=18.921±0.006Å, b=12.952±0.003Å, c=9.276±0.002Å and β=91.32±0.03°. The average size of a well ground specimen of crystallites was 60nm. The average micro-strain, e.g., 45×10(-4) has been tentatively attributed to fatty chain conformational disorder. The unit cell parameters, including the lamellar thickness, of COC crystal is very closely similar to those of another, structurally similar cholesterol ester, e.g., cholesteryl oleate (CO) crystal, space group P2(1), type II monolayer. Type I monolayer structure has been established for COC on the basis of the intensity calculations of the XRD profiles of both CO and COC. The dipolar and structural disorder in a 4:1 molar, binary mixture of CO and COC can be accommodated in an induced smectic phase with a lamellar thickness, which is nearly equal to that of pure CO or pure COC.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP17110519	Cholesteryl oleyl carbonate		17110-51-9	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: