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Crystal Structure of Pyrimidine-Nucleoside Phosphorylase From Bacillus Subtilis in Complex With Imidazole and Sulfate

Crystal Structure of Pyrimidine-Nucleoside Phosphorylase From Bacillus Subtilis in Complex With Imidazole and Sulfate

V V Balaev, I I Prokofev, A G Gabdoulkhakov, C Betzel, A A Lashkov

Acta Crystallogr F Struct Biol Commun. 2018 Apr 1;74(Pt 4):193-197.

PMID: 29633966

Abstract:

Pyrimidine-nucleoside phosphorylase catalyzes the phosphorolytic cleavage of thymidine and uridine with equal activity. Investigation of this protein is essential for anticancer drug design. Here, the structure of this protein from Bacillus subtilis in complex with imidazole and sulfate is reported at 1.9 Å resolution, which is an improvement on the previously reported structure at 2.6 Å resolution. The localization and position of imidazole in the nucleoside-binding site reflects the possible binding of ligands that possess an imidazole ring.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9055350	Pyrimidine nucleoside phosphorylase		9055-35-0	Price

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