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Cu(OTf) 2-Catalyzed Pummerer Coupling of β-Ketosulfoxides

Regev Parnes, Hagai Reiss, Doron Pappo

J Org Chem. 2018 Jan 19;83(2):723-732.

PMID: 29293340

Abstract:

The copper(II) trifluoromethanesulfonate-catalyzed Pummerer reaction of β-ketosulfoxides with 1,3-dicarbonyl compounds or π-nucleophiles such as phenols, arenes, and tetraallylsilane is reported. The mild conditions provide an efficient entry to a novel class of polysubstituted 3-alkylthiofuran and polysubstituted 3-thiobenzofuran heterocycles from readily available materials.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1112669 Tetraallylsilane Tetraallylsilane 1112-66-9 Price
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