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Curcumin and Tetrahydrocurcumin Induce Cell Death in Ara-C-resistant Acute Myeloid Leukemia

Curcumin and Tetrahydrocurcumin Induce Cell Death in Ara-C-resistant Acute Myeloid Leukemia

Yu-Hsin Tseng, Shyh-Shin Chiou, Jui-Pei Weng, Pei-Chin Lin

Phytother Res. 2019 Apr;33(4):1199-1207.

PMID: 30834607

Abstract:

Most anticancer agents induce cancer cell death; however, multidrug-resistant cancers often lead to treatment failure. The effective use of curcumin as an anticancer agent has been demonstrated in clinical trials. Tetrahydrocurcumin, a major curcumin metabolite, exhibits pharmacological activities similar to those of curcumin. Curcumin induces cell death mainly through the apoptosis pathway, and tetrahydrocurcumin induces cell death mainly via an autophagy pathway in HL60 cells. Here, we investigated whether curcumin and tetrahydrocurcumin can induce apoptosis- and autophagy-mediated cell deaths in Ara-C-resistant cancer cells, respectively. The results demonstrated that curcumin and tetrahydrocurcumin induced cell death by apoptosis and autophagy, respectively, in Ara-C-resistant HL60 cells. Thus, curcumin and tetrahydrocurcumin have potential applications in the treatment of acute myeloid leukemia with Ara-C resistance.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP36062041	Tetrahydrocurcumin		36062-04-1	Price

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