Home
Resources
Publications
Curcumol: From Plant Roots to Cancer Roots

Curcumol: From Plant Roots to Cancer Roots

Wei Wei, Azhar Rasul, Ayesha Sadiqa, Iqra Sarfraz, Ghulam Hussain, Bushra Nageen, Xintong Liu, Nobumoto Watanabe, Zeliha Selamoglu, Muhammad Ali, Xiaomeng Li, Jiang Li

Int J Biol Sci. 2019 Jun 4;15(8):1600-1609.

PMID: 31360103

Abstract:

Natural products, an infinite treasure of bioactive scaffolds, have provided an excellent reservoir for the discovery of drugs since millennium. These naturally occurring, biologically active and therapeutically effective chemical entities have emerged as novel paradigm for the prevention of various diseases. This review aims to give an update on the sources as well as pharmacological profile of curcumol, a pharmacologically active sesquiterpenoid, which is an imperative bioactive constituent of several plants mainly from genus Curcuma. Curcumol has potential to fight against cancer, oxidative stress, neurodegeneration, microbial infections, and inflammation. Curcumol has been documented as potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-κB which are generally deregulated in several cancers. The reported data reveals multitarget activity of curcumol in cancer treatment suggesting its importance as anticancer drug in future. It is speculated that curcumol may provide an excellent opportunity for the cure of cancer but further investigations on mechanism of its action and preclinical trials are still mandatory to further validate the potential of this natural cancer killer in anticancer therapies.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP4871970	( −)-Curcumol		4871-97-0	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: