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Curcumol Inhibits Colorectal Cancer Proliferation by Targeting miR-21 and Modulated PTEN/PI3K/Akt Pathways

Curcumol Inhibits Colorectal Cancer Proliferation by Targeting miR-21 and Modulated PTEN/PI3K/Akt Pathways

Haowei Liu, Juan Wang, Yexing Tao, Xumei Li, Jianli Qin, Zhun Bai, Bixia Chi, Wei Yan, Xu Chen

Life Sci. 2019 Mar 15;221:354-361.

PMID: 30811964

Abstract:

Aims:
The purpose of this study was to demonstrate how curcumol affected the expression of miR-21 and whether its effects on miR-21 was associated with the activation of PTEN/PI3K/Akt pathways in CRC cells.
Main methods:
MTT and xenograft assay were used to examine how curcumol inhibits colorectal cancer (CRC) cells' growth. Q-PCR and western blot analysis were employed to test the role of miR-21 in the inhibition of curcumol on proliferation and PTEN/PI3K/Akt pathways of CRC cells.
Key findings:
We found that curcumol effectively inhibited CRC cells from proliferating via the PTEN/PI3K/Akt pathways and reduced expression of miR-21 both in vitro and in vivo. miR-21 mimics were found to decrease the protein level of PTEN and increase the expression of PI3K, phospho-Akt (p-Akt) and NF-κB, while miR-21 sponge (miR-21-SP) enhanced the expression of PTEN and reduced the activity of PI3K, Akt and NF-κB. Furthermore, miR-21-SP strengthened the role of curcumol in up-regulating PTEN and inhibiting PI3K/Akt pathways, but miR-21 reversed the effect of curcumol on the PTEN/PI3K/Akt pathways.
Significance:
Our research demonstrated that curcumol reduced the proliferation of CRC cells through PTEN/PI3K/Akt by targeting miR-21 and miR-21 could be a target molecule of curcumol for CRC treatment.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP4871970	( −)-Curcumol		4871-97-0	Price

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