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Cyanidin-3- O-glucoside chloride acts synergistically with luteolin to inhibit the growth of colon and breast carcinoma cells

Cyanidin-3- O-glucoside chloride acts synergistically with luteolin to inhibit the growth of colon and breast carcinoma cells

Huanli Yin, Langtao Wang, Min Wu, Yuan Liu, Ningxi Li, Tianyu Chen

Pharmazie. 2019 Jan 1;74(1):54-61.

PMID: 30782251

Abstract:

In this study, we investigated whether the combination of cyanidin-3-O-glucoside chloride and luteolin could inhibit the growth of HCT-8 colon and MCF-7 breast carcinoma cells, and whether the effect of the combination was greater than the effect of either drug on its own. Growth inhibition was assessed using the CCK-8 assay, level of apoptosis and cell cycle distribution were determined using flow cytometry, and the mechanism of apoptosis induction was explored using a colorimetric assay of caspases-3 and -9. Experiments indicated that combination treatment inhibited proliferation and increased apoptosis in both cell lines to a greater extent than either drug on its own. These results suggest that luteolin and cyanidin-3-O-glucoside chloride synergistically inhibitthe growth of colon cancer and breast cancer cells. This work justifies further effort to develop this potential combination therapy.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP7084244-B	Cyanidin 3-O-glucoside chloride		7084-24-4	Price

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