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Cyclo-oxygenase-1-selective Inhibitor SC-560

Cyclo-oxygenase-1-selective Inhibitor SC-560

Sihui Long, Kathryn L Theiss, Tonglei Li, Charles D Loftin

Acta Crystallogr Sect E Struct Rep Online. 2009 Jan 23;65(Pt 2):o360.

PMID: 21581958

Abstract:

In the title compound, 5-(4-chloro-phen-yl)-1-(4-methoxy-phen-yl)-3-(trifluoro-meth-yl)-1H-pyrazole (SC-560), C(17)H(12)ClF(3)N(2)O, a COX-1-selective inhibitor, the dihedral angles between the heterocycle and the chlorobenzene and methoxybenzene rings are 41.66 (6) and 43.08 (7)°, respectively. The dihedral angle between the two phenyl rings is 59.94 (6)°. No classic hydrogen bonds are possible in the crystal, and intermolecular interactions must be mainly of the dispersion type. This information may aid the identification of dosage formulations with improved oral bioavailability.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP188817132-A	SC-560		188817-13-2	Price

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