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γ-Cyclodextrin-phenylacetic Acid Mesh as a Drug Trap

γ-Cyclodextrin-phenylacetic Acid Mesh as a Drug Trap

Hyeong Sup Yu, Jae Min Lee, Yu Seok Youn, Kyung Taek Oh, Kun Na, Eun Seong Lee

Carbohydr Polym. 2018 Mar 15;184:390-400.

PMID: 29352934

Abstract:

In this study, we developed a nanoporous biodegradable mesh, bioinspired by the spider web, which is prepared via electrospinning using γ-cyclodextrin (γ-CD) conjugated with phenylacetic acid (PA), named γ-CDP. The resulting γ-CDP has a microfibrous or microspherical shape and contains drug trap meshlike γ-CD pores. These γ-CDP micromeshes (microspheres or microfibers) enable efficient drug capture and drug transport into deep γ-CDP nanocompartments or out of the γ-CDP web, resulting in a driving domain for a 4-week drug release. When used to deliver chemotherapeutic agents to xenografted tumors, the γ-CDP implants caused nearly complete tumor regression for 4 weeks after single administration. This strategy of a drug trap biodegradable mesh (with low density) will make drug containers uniquely attractive for the development of therapeutic implants and functional biomedical devices.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP17465860-B	γ-Cyclodextrin		17465-86-0	Price

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