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Cyclooxygenase-2 Inhibitors in Ginger (Zingiber Officinale)

Cyclooxygenase-2 Inhibitors in Ginger (Zingiber Officinale)

Richard B van Breemen, Yi Tao, Wenkui Li

Fitoterapia. 2011 Jan;82(1):38-43.

PMID: 20837112

Abstract:

Ginger roots have been used to treat inflammation and have been reported to inhibit cyclooxygenase (COX). Ultrafiltration liquid chromatography mass spectrometry was used to screen a chloroform partition of a methanol extract of ginger roots for COX-2 ligands, and 10-gingerol, 12-gingerol, 8-shogaol, 10-shogaol, 6-gingerdione, 8-gingerdione, 10-gingerdione, 6-dehydro-10-gingerol, 6-paradol, and 8-paradol bound to the enzyme active site. Purified 10-gingerol, 8-shogaol and 10-shogaol inhibited COX-2 with IC(50) values of 32 μM, 17.5 μM and 7.5 μM, respectively. No inhibition of COX-1 was detected. Therefore, 10-gingerol, 8-shogaol and 10-shogaol inhibit COX-2 but not COX-1, which can explain, in part, the anti-inflammatory properties of ginger.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP36700455	8-Shogaol		36700-45-5	Price

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