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Cyclophosphamide

Cyclophosphamide

PMID: 30000732

Abstract:

Cyclophosphamide appears in milk in potentially toxic amounts; additionally, highly toxic active metabolites could add to the risk to the infant. Neutropenia has been reported in 2 infants whose mothers breastfed them while receiving cyclophosphamide. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[1] Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant. Most sources consider breastfeeding to be contraindicated during maternal cytotoxic antineoplastic drug therapy, especially alkylating agents such as cyclophosphamide.[2] It appears to take more than 21 days for the drug and its metabolites to be eliminated from breastmilk. Some authors' data suggest that it might take 6 weeks for milk levels to drop to a safe level afer a dose of cyclophosphamide 750 mg/sq. m.[3]

Chemicals Related in the Paper:

Catalog Number	Product Name	CAS Number	Price
ALP144678637	NSC 668036 hydrate	144678-63-7 (anhydrous)	Price
ALP3567257	Sulcofuron-sodium monohydrate	3567-25-7 (anhydrous)	Price
AP201740809	Boc-Leu-OH-1-13C monohydrate	201740-80-9	Price

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