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α-cyperone Alleviates Lung Cell Injury Caused by Staphylococcus Aureus via Attenuation of α-hemolysin Expression

α-cyperone Alleviates Lung Cell Injury Caused by Staphylococcus Aureus via Attenuation of α-hemolysin Expression

Mingjing Luo, Jiazhang Qiu, Yu Zhang, Jianfeng Wang, Jing Dong, Hongen Li, Bingfeng Leng, Qian Zhang, Xiaohan Dai, Xiaodi Niu, Shuhua Zhao, Xuming Deng

J Microbiol Biotechnol. 2012 Aug;22(8):1170-6.

PMID: 22713997

Abstract:

In this study, we aimed to evaluate the effect of α- cyperone on S. aureus. We used a hemolysin test to examine the hemolytic activity in supernatants of S. aureus cultured with increasing concentrations of α- cyperone. In addition, we evaluated the production of α- hemolysin (Hla) by Western blotting. Real-time RT-PCR was performed to test the expression of hla (the gene encoding Hla) and agr (accessory gene regulator). Furthermore, we investigated the protective effect of α- cyperone on Hla-induced injury of A549 lung cells by live/ dead and cytotoxicity assays. We showed that in the presence of subinhibitory concentrations of α-cyperone, Hla production was markedly inhibited. Moreover, α- cyperone protected lung cells from Hla-induced injury. These findings indicate that α-cyperone is a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium. Thus, α-cyperone may provide the basis for a new strategy to combat S. aureus pneumonia.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP473085	α-Cyperone		473-08-5	Price

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