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Cytochrome P450 for Citreohybridonol Synthesis: Oxidative Derivatization of the Andrastin Scaffold

Yudai Matsuda, Zhiyang Quan, Takaaki Mitsuhashi, Chang Li, Ikuro Abe

Org Lett. 2016 Jan 15;18(2):296-9.

PMID: 26731665

Abstract:

A biosynthetic gene cluster similar to that for andrastin A (1) was discovered in Emericella variecolor NBRC 32302. Ctr-P450, a cytochrome P450 uniquely present in the cluster, was coexpressed with the andrastin A biosynthetic genes, leading to the production of the antifeedant agent citreohybridonol (4), along with four new andrastin derivatives. The results revealed the unusual multifunctionality of Ctr-P450 and indicated that this approach can be applied for further natural product diversification.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP174232429 Andrastin A Andrastin A 174232-42-9 Price
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