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Cytochrome P450-Mediated λ-Cyhalothrin-Resistance in a Field Strain of Helicoverpa Armigera From Northeast China

Cytochrome P450-Mediated λ-Cyhalothrin-Resistance in a Field Strain of Helicoverpa Armigera From Northeast China

Zi-Guo Wang, Shan-Shan Jiang, David Mota-Sanchez, Wei Wang, Xin-Ru Li, Yu-Lin Gao, Xu-Peng Lu, Xue-Qing Yang

J Agric Food Chem. 2019 Apr 3;67(13):3546-3553.

PMID: 30882220

Abstract:

Resistance to pyrethroid and organophosphate insecticides has been a growing problem in the management of cotton bollworm Helicoverpa armigera (Hübner) populations in the Yangtze River and Yellow River valleys of China, but resistance status and mechanisms of H. armigera populations from northeast China are less documented. In this study, a field strain collected from Shenyang in northeast China (SYR) is up to 16-fold more resistant than a susceptible strain (SS) to λ-cyhalothrin, while the resistance level to phoxim remained low (2.6-fold). Synergist tests and enzymatic assays show that increased cytochrome P450 monooxygenase (P450) activity is the main mechanism for λ-cyhalothrin resistance. Eight out of 10 genes from CYP6 and CYP9 subfamilies were significantly overexpressed in the SYR strain, and CYP6AE11 was the mostly overexpressed P450 (59-fold). These results suggest that overexpression of multiple P450 enzymes contributes to λ-cyhalothrin resistance in the SYR strain of H. armigera from northeast China.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS353708	λ-Cyhalothrin-(phenoxy-d5)			Price

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