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Cytoprotection by 16,16-dimethylprostaglandin E2. Role of Gastric Juice and Mucus Gel Layer

Cytoprotection by 16,16-dimethylprostaglandin E2. Role of Gastric Juice and Mucus Gel Layer

Y Taniguchi, Y Yoshida, K Kimura, M Mato

J Clin Gastroenterol. 1992;14 Suppl 1:S52-8.

PMID: 1629578

Abstract:

A mechanism of cytoprotection by 16,16-dimethylprostaglandin E2 (16,16-dimethyl-PGE2) was investigated in rats with respect to possible roles of the gastric juice and the mucus gel layer. 16,16-Dimethyl-PGE2 significantly increased the volume of gastric juice and mucus thickness. In a gastric juice-emptied stomach, 16,16-dimethyl-PGE2 protected the gastric mucosa against 30% ethanol, but not against 40% ethanol. Moreover, this agent did not show any cytoprotective action even against 30% ethanol when both gastric juice and mucus gel were removed. In this situation there was no histological change in the depth of injury, whether 16,16-dimethyl-PGE2 was given as pretreatment or not. These results suggest that there are two mechanisms that may play major roles in the cytoprotection of the gastric mucosa by 16,16-dimethyl-PGE2: (a) dilution of necrotizing agents by increased gastric juice and (b) thickening of the mucus gel layer.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP39746253	16,16-Dimethylprostaglandin E2		39746-25-3	Price

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