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Cytotoxic Activity of Antioxidant Constituents From Hypericum Triquetrifolium Turra

F Conforti, M R Loizzo, A G Statti, F Menichini

Nat Prod Res. 2007 Jan;21(1):42-6.

PMID: 17365688

Abstract:

The Sulforodamine B (SRB) assay was used to test cytotoxicity against four human cancer cell lines and one normal cell line of antioxidant constituents isolated from Hypericum triquetrifolium Turra. Methanolic extract and pure compounds were tested against the large cell lung carcinoma cell line COR-L23, the hepatocellular carcinoma cell line HepG-2, renal cell adenocarcinoma ACHN, the amelanotic melanoma cell line C32 and normal human foetal lung MRC5. The results showed that I3-II8-biapigenin exhibited strong cytotoxic activity (IC50 = 5.73 micro g mL(-1)) showing a certain degree of selectivity against the different cell types.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP101140061 I3,II8-Biapigenin I3,II8-Biapigenin 101140-06-1 Price
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