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Cytotoxic and Genotoxic Effect of Oxyfluorfen on Hemocytes of Biomphalaria Glabrata

Cytotoxic and Genotoxic Effect of Oxyfluorfen on Hemocytes of Biomphalaria Glabrata

Maíra de Vasconcelos Lima, Williams Nascimento de Siqueira, Hianna Arely Milca Fagundes Silva, José de Melo Lima Filho, Elvis Joacir de França, Ana Maria Mendonça de Albuquerque Melo

Environ Sci Pollut Res Int. 2019 Feb;26(4):3350-3356.

PMID: 30506409

Abstract:

Chemicals released from anthropogenic activities such as industry and agriculture often end up in aquatic ecosystems. These substances can cause serious damage to these ecosystems, thus threatening the conservation of biodiversity. Among these substances are pesticides, such as oxyfluorfen, a herbicide used for the control of grasses and weeds. Considering its widespread use, it is important to investigate the possible toxicity of this compound to aquatic organisms, especially invertebrates. Hence, the use of biological systems able to detect such effects is of great importance. The mollusk Biomphalaria glabrata has been shown to be useful as an environmental indicator to assess the potential ecological effects of physical and chemical stressors in freshwater environments. The present study sought to detect mutagenic changes in hemocytes of B. glabrata exposed to oxyfluorfen. To perform these tests, this study used ten animals per group, exposed acutely (48 h) and chronically (15 days) to oxyfluorfen. The herbicide concentrations were 0.125, 0.25, and 0.5 mg/L. The results showed that oxyfluorfen induced significant frequencies of micronuclei, binucleated cells, and apoptosis in hemocytes of mollusks when compared to the control group. Unlike chronic exposure, acute exposure was dose-dependent. The present study's results demonstrate the cytotoxic and genotoxic effects of oxyfluorfen on hemocytes of B. glabrata.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS353757	Oxyfluorfen-(ethoxy-d5)			Price

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