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Cytotoxic Apigenin Derivatives From Chrysopogon Aciculatis

Chien-Chang Shen, Jing-Jy Cheng, Horng-Liang Lay, Szu-Yuan Wu, Ching-Li Ni, Che-Ming Teng, Chien-Chih Chen

J Nat Prod. 2012 Feb 24;75(2):198-201.

PMID: 22272829

Abstract:

Four new apigenin derivatives, 7-de-O-methylaciculatin, 8-C-β-D-boivinopyranosylapigenin, aciculatinone, and 4'-O-glucosylaciculatin, along with eight known compounds, apigenin-8-carbaldehyde, kaempferol, tricin, taxifolin, 6,7,4'-trihydroxyflavone, trans-oxyresveratrol, aciculatin, and luteolin-7-sulfate, were isolated from an ethanolic extract of Chrysopogon aciculatis. Their chemical structures were elucidated by spectroscopic methods. Among the known compounds, the natural occurrence of apigenin-8-carbaldehyde and luteolin-7-sulfate is demonstrated for the first time. Some of the isolates were evaluated for cytotoxic activity against human cancer cell lines including MCF-7, H460, HT-29, and CEM.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP29700229 trans-Oxyresveratrol trans-Oxyresveratrol 29700-22-9 Price
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