0

Cytotoxic Cucurbitane Triterpenoids Isolated From the Rhizomes of Hemsleya Amabilis

Xu-Bing Chen, Guang-Yong Chen, Jun-Hua Liu, Min Lei, Yu-Hui Meng, De-An Guo, Xuan Liu, Li-Hong Hu

Fitoterapia. 2014 Apr;94:88-93.

PMID: 24462673

Abstract:

Two new cucurbitane triterpenoids, 7β-hydroxycucurbitacin F-25-O-acetate (1) and 2β,3β,20(S),26,27-pentahydroxy-16α,23(S)-epoxycucurbita-5,24-dien-11-one (2) along with eleven known cucurbitane triterpenoids (3-13, resp.) were isolated from the rhizomes of Hemsleya amabilis Diels. The chemical structures of the new isolated compounds were elucidated unambiguously by spectroscopic data analysis. The cytotoxic activities of the isolated cucurbitane triterpenoids were evaluated against the HeLa human cancer cell lines. Hemslecin A (5), the main ingredient of H. amabilis, exhibited the significant cytotoxicity with IC50 value of 0.389 μM.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP58546342 Hemslecin A Hemslecin A 58546-34-2 Price
qrcode