Home
Resources
Publications
Cytotoxicity of 6-biopterin to Human Melanocytes

Cytotoxicity of 6-biopterin to Human Melanocytes

K U Schallreuter, G Büttner, M R Pittelkow, J M Wood, N N Swanson, C Körner

Biochem Biophys Res Commun. 1994 Oct 14;204(1):43-8.

PMID: 7945390

Abstract:

(6R)5,6,7,8 tetrahydrobiopterin (6-BH4) is an important cofactor in the regulation of melanogenesis in melanocytes, where it controls: (a) the supply of L-tyrosine from L-phenylalanine via phenylalanine hydroxylase, and (b) regulates directly dopaquinone formation from L-tyrosine via tyrosinase. 6-BH4 undergoes redox-cycling by its oxidation to quinonoid dihydrobiopterin (qBH2) and to 6-biopterin through consecutive two electron oxidation reactions. The oxidized cofactor 6-biopterin (0.2 x 10(-6) M) is extremely cytotoxic to human melanocytes under in vitro conditions. Consequently, its reduction to 6-BH4 via q-BH2 is essential to melanocyte viability. In addition, the results herein show for the first time that human thioredoxin reductase has the capacity to reduce 6-biopterin to q-BH2 where further reduction to 6-BH4 follows via dihydropteridine reductase or reduced glutathione.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP22150761	6-Biopterin		22150-76-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: