Home
Resources
Publications
Cytotoxicity of Titanium Carbonitride Coatings for Prostodontic Alloys With Different Amounts of Carbon and Nitrogen

Cytotoxicity of Titanium Carbonitride Coatings for Prostodontic Alloys With Different Amounts of Carbon and Nitrogen

Katarzyna Banaszek, Leszek Klimek, Emilia Zgorzynska, Amanda Swarzynska, Anna Walczewska

Biomed Mater. 2018 Apr 16;13(4):045003.

PMID: 29570097

Abstract:

The aim of our work was to examine the cytotoxicity of NiCr alloys coated with Ti(C,N) with different amounts of C and N in the layer on human gingival fibroblasts. Cells were cultured for 24 hours in the alloy extracts or on the surface of tested materials. The viability of the cells exposed to 1-, 3-, 5- and 7-day extracts did not change in comparison to the viability of cells cultured in a control medium assayed by an MTT test. Moreover, the flow cytometry analysis of fibroblasts cultured in direct contact with tested alloys revealed that all coatings except TiC did not induce apoptosis or necrosis. Interestingly, 24 hour fibroblast culture on alloys with Ti(C,N) coatings showed that the number of fibroblasts adhered to these alloys, evaluated by scanning electron microscope, increased with an increase in the content of nitrogen in the layer. The present study demonstrates that Ti(C,N) coatings were not cytotoxic and did not induce apoptosis in Ti(C,N) extracts, nor in direct contact with gingival fibroblasts, and can be considered for biomedical applications in the future.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP12654863	Titanium carbonitride		12654-86-3	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: