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D-α-tocopheryl Polyethylene Glycol 1000 Succinate Functionalized Nanographene Oxide for Cancer Therapy

D-α-tocopheryl Polyethylene Glycol 1000 Succinate Functionalized Nanographene Oxide for Cancer Therapy

Duarte de Melo-Diogo, Cleide Pais-Silva, Elisabete C Costa, Ricardo O Louro, Ilídio J Correia

Nanomedicine (Lond). 2017 Mar;12(5):443-456.

PMID: 28181461

Abstract:

Aim:
To evaluate the therapeutic capacity of D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)-functionalized nanographene oxide (nGO) in breast cancer cells.
Methods:
TPGS-functionalized nGO-based materials were obtained through two different approaches: a simple sonication method and a one-pot hydrothermal treatment.
Results:
TPGS coating successfully improved the stability of the nGO-based materials. The nanomaterials that underwent the hydrothermal procedure generated a 1.4- to 1.6-fold higher temperature variation under near infrared laser irradiation than those prepared only by sonication. In vitro, the TPGS/nGO derivatives reduced breast cancer cells' viability and had an insignificant effect on healthy cells. Furthermore, the combined application of TPGS/nGO derivatives and near infrared light generated an improved therapeutic effect.
Conclusion:
TPGS/nGO derivatives are promising materials for breast cancer phototherapy.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP25322683-A	Polyethylene glycol 1000		25322-68-3	Price

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