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Dafadine Inhibits DAF-9 to Promote Dauer Formation and Longevity of Caenorhabditis Elegans

Genna M Luciani, Lilia Magomedova, Rachel Puckrin, Malene L Urbanus, Iain M Wallace, Guri Giaever, Corey Nislow, Carolyn L Cummins, Peter J Roy

Nat Chem Biol. 2011 Nov 6;7(12):891-3.

PMID: 22057127

Abstract:

The DAF-9 cytochrome P450 is a key regulator of dauer formation, developmental timing and longevity in the nematode Caenorhabditis elegans. Here we describe the first identified chemical inhibitor of DAF-9 and the first reported small-molecule tool that robustly induces dauer formation in typical culture conditions. This molecule (called dafadine) also inhibits the mammalian ortholog of DAF-9(CYP27A1), suggesting that dafadine can be used to interrogate developmental control and longevity in other animals.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1065506695 Dafadine A Dafadine A 1065506-69-5 Price
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