Home
Resources
Publications
DCP-LA Exerts an Antiaging Action on the Skin

DCP-LA Exerts an Antiaging Action on the Skin

Tomoyuki Nishizaki

Skin Pharmacol Physiol. 2016;29(3):157-60.

PMID: 27310436

Abstract:

The present study assessed the possibility for the linoleic acid derivative 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) as an antiaging compound for the skin by assaying senescence-associated β-galactosidase (SA-β-Gal), a biomarker of senescence and cell viability. The nitric oxide (NO) donor sodium nitroprusside (SNP) increased in SA-β-Gal-positive cells in cultured human fibroblasts and mouse keratinocytes, and DCP-LA significantly inhibited the effect of SNP. Moreover, SNP induced cell death in cultured mouse keratinocytes, and DCP-LA significantly prevented NO stress-induced death of keratinocytes. Taken together, these results indicate that DCP-LA exerts an antiaging action on the skin.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP28399317	DCP-LA		28399-31-7	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: