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DEAE-dextran Hydrochloride Behaviour in Aqueous solution-The Effect of Ionic Strength and Concentration

DEAE-dextran Hydrochloride Behaviour in Aqueous solution-The Effect of Ionic Strength and Concentration

Michal Kalina, Andrea Kargerová, Miloslav Pekař

Carbohydr Polym. 2019 Sep 15;220:163-169.

PMID: 31196536

Abstract:

DEAE-dextran hydrochloride is a positively charged biocompatible polyelectrolyte. Its behaviour in aqueous solutions - the changes in its colloidal characteristics and resulting conformation changes - were investigated using a combination of light scattering, densitometry and ultrasound spectrometry. The results indicated the formation of a voluminous, hydrated and coiled conformation of chains having average particle sizes in the range of units of microns at low ionic strength. This phenomenon was supported by an increase in DEAE-dextran hydrochloride concentration in the solution. The increase in ionic strength caused the shielding of DEAE-dextran hydrochloride charges on its chain, resulting in the destabilization of the conformation arrangement of the polyelectrolyte and the formation of denser, more compact and stiffer structures having smaller particle sizes. The proposed model of DEAE-dextran hydrochloride density in the studied environments (distilled water, NaCl solutions) showed the possibility of using a single equation model to calculate the overall density of the system.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9064919	DEAE-Dextran hydrochloride		9064-91-9	Price

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