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Deceiving Proteins! A Case of Lymphoma and High Creatinine

Deceiving Proteins! A Case of Lymphoma and High Creatinine

El Hakem Abdelkarim Metraiah, Helen Regan, Johanna Louw, Dana Kidder

BMJ Case Rep. 2017 Jan 23;2017:bcr2016217946.

PMID: 28115403

Abstract:

Estimation of kidney function by measuring serum creatinine is one the commonest laboratory tests conducted in clinical practice. Enzymatic methods are often used to measure serum creatinine. Clinicians should be aware of the limitations of these methods, such as test interference with paraproteins.We present a case of falsely elevated serum creatinine in a patient referred for renal biopsy. The combination of fluctuating creatinine and normal blood urea level was unusual. Serum protein electrophoresis revealed the presence of an IgM paraprotein. Further investigations confirmed an underlying diagnosis of lymphoplasmacytoid lymphoma. This case highlights how IgM paraprotein can interfere with creatinine estimation by enzymatic assay and the utility of alternative methods of estimating serum creatinine.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AS2121437	Human serum (high creatinine)			Price

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