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Defined High Molar Mass Poly(2-Oxazoline)s

Defined High Molar Mass Poly(2-Oxazoline)s

Bryn D Monnery, Valentin V Jerca, Ondrej Sedlacek, Bart Verbraeken, Rachel Cavill, Richard Hoogenboom

Angew Chem Int Ed Engl. 2018 Nov 19;57(47):15400-15404.

PMID: 30303605

Abstract:

Poly(2-alkyl-2-oxazoline)s (PAOx) are regaining interest for biomedical applications. However, their full potential is hampered by the inability to synthesise uniform high-molar mass PAOx. In this work, we proposed alternative intrinsic chain transfer mechanisms based on 2-oxazoline and oxazolinium chain-end tautomerisation and derived improved polymerization conditions to suppress chain transfer, allowing the synthesis of highly defined poly(2-ethyl-2-oxazoline)s up to ca. 50 kDa (dispersity (Ð) <1.05) and defined polymers up to at least 300 kDa (Ð<1.2). The determination of the chain transfer constants for the polymerisations hinted towards the tautomerisation of the oxazolinium chain end as most plausible cause for chain transfer. Finally, the method was applied for the preparation of up to 60 kDa molar mass copolymers of 2-ethyl-2-oxazoline and 2-methoxycarbonylethyl-2-oxazoline.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS74609	Poly(2-ethyl-2-oxazoline)			Price

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