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Degradable and Thermosensitive Microgels Synthesized via Simultaneous Quaternization and Siloxane Condensation

Degradable and Thermosensitive Microgels Synthesized via Simultaneous Quaternization and Siloxane Condensation

Xianjing Zhou, Haipeng Lu, Feng Chen, Lingli Kong, Feng Zhang, Wei Zhang, Jingjing Nie, Binyang Du, Xinping Wang

Langmuir. 2019 May 7;35(18):6145-6153.

PMID: 30983362

Abstract:

Degradable and thermosensitive microgels were successfully prepared via simultaneous quaternization and siloxane condensation during surfactant-free emulsion polymerization, with N-vinylcaprolactam as the main monomer and 1-vinylimidazole (VIM) as the comonomer, in the presence of (3-bromopropyl)trimethoxysilane (BPTMOS). The formation mechanism of cross-linking network was attributed to the hydrolysis and condensation of the methoxysilyl groups of BPTMOS and the quaternization of imidazole moiety of VIM by the bromine group of BPTMOS, leading to the microgels. The microgels were spherical in shape with a narrow size distribution, stable in an acidic buffer solution, but degradable in neutral and alkaline solutions. The presence of quaternized imidazolium in the same chain segment of Si-O-Si cross-linking points promoted the decomposition of Si-O-Si bonds and hence the degradation of the microgels. The obtained microgels could load and release the model drug, doxorubicin. The size, thermosensitivity, stability, degradation rate, and drug release behavior of the resultant microgels could be tuned by controlling the cross-linking degree, chemical composition, and degradation medium.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP51826905	(3-Bromopropyl)trimethoxysilane		51826-90-5	Price

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