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[Degradation Kinetics of Chlorogenic Acid, Cryptochlorogenic Acid, and Neochlorogenic Acid at Neutral and Alkaline pH Values]

[Degradation Kinetics of Chlorogenic Acid, Cryptochlorogenic Acid, and Neochlorogenic Acid at Neutral and Alkaline pH Values]

Peng Zhu, Xiao-lei Miao, Yong Chen

Yao Xue Xue Bao. 2016 Jan;51(1):122-6.

PMID: 27405173

Abstract:

The degradation kinetics of chlorogenic acid (5-CQA), cryptochlorogenic acid (4-CQA), and neochlorogenic acid (3-CQA) in aqueous solution at 37 degrees C and different pH values (7.05, 7.96, 9.25) were investigated in the present work. The results indicated that 3-, 4- and 5-CQA tended to remain stable in acidic pH circumstance, and unstable in neutral and alkaline pH circumstance. With the increase of the alkalinity, the degradation of 3-, 4- and 5-CQA was increased leading to a less amount of total CQA and was satisfactorily described by the Weibull equation. Meanwhile, caffeic acid was not detected after the degradation of CQA. Moreover, the degradation of 3-CQA and 5-CQA tended to be converted to 4-CQA, and the degradation of 4-CQA tended to be converted to 3-CQA rather than 5-CQA. The comparison of the degradation kinetics parameters of 3-, 4- and 5-CQA at neutral and alkaline pH values showed that the orders of the rate constant (k) values were 4-CQA > 3-CQA > 5-CQA, while the orders of the degradation half life (t½) values were 4-CQA < 3-CQA < 5-CQA, indicating the orders of the stabilities of 3-, 4- and 5-CQA at 37 degrees C and neutral and alkaline pH values were 4-CQA < 3-CQA < 5-CQA.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP905997	Cryptochlorogenic acid		905-99-7	Price
AP906332-A	Neochlorogenic acid		906-33-2	Price

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