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Degradation of Verapamil Hydrochloride in Water by Gliding Arc Discharge

Degradation of Verapamil Hydrochloride in Water by Gliding Arc Discharge

Syam Krishna, Alan Maslani, Tomasz Izdebski, Marta Horakova, Sarka Klementova, Petr Spatenka

Chemosphere. 2016 Jun;152:47-54.

PMID: 26953731

Abstract:

This study investigated the influence of gliding arc plasma discharge on the degradation of Verapamil hydrochloride in water. The plasma discharge was characterized by means of optical emission spectroscopy. Spectra of various atomic and molecular species were observed. Aqueous solution of Verapamil hydrochloride was exposed to gliding arc discharge operated in continuous discharge at atmospheric pressure and room temperature. The identification of Verapamil, the degradation mechanisms of Verapamil and its transformation products were performed using liquid chromatography - mass spectrometry (HPLC-MS). Experimental results indicate that the atmospheric pressure gliding arc plasma treatment has noticeable effects on Verapamil with satisfactory degradation efficiency. Plausible mechanisms of the degradation were discussed.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP152114	(±)-Verapamil hydrochloride		152-11-4	Price

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